<p>Temperature, H<sub>2</sub>O, and O<sub>3</sub> profiles, as well as CO<sub>2</sub>, N<sub>2</sub>O, CH<sub>4</sub>, CFC12, and SST scalar anomalies are computed using a clear subset of AIRS observations over ocean for the first 16-years of NASA's EOS-AQUA AIRS operation. The AIRS Level 1c radiances are averaged over 16 days and 40 equal-area zonal bins and then converted to brightness temperature anomalies. Geophysical anomalies are retrieved from the brightness temperature anomalies using a relatively standard optimal estimation approach. The CO<sub>2</sub>, N<sub>2</sub>O, CH<sub>4</sub>, and CFC12 anomalies are derived by applying a vertically uniform multiplicative shift to each gas in order to obtain an estimate for the ngas mixing ratio. The minor gas anomalies are compared to the NOAA ESRL in-situ values and used to estimate the radiometric stability of the AIRS radiances. Similarly the retrieved SST anomalies are compared to the SST values used in the ERA-Interim reanalysis and to NOAA's OISST SST product. These inter-comparisons strongly suggest that many AIRS channels are stable to better than 0.02 to 0.03 K/Decade, well below climate trend levels, indicating that the AIRS blackbody is not drifting. However, detailed examination of the anomaly retrieval residuals (observed minus computed) show various small unphysical shifts that correspond to AIRS hardware events (shutdowns, etc.). Some examples are given highlighting how the AIRS radiances stability could be improved, especially for channels sensitive to N<sub>2</sub>O and CH<sub>4</sub>. The AIRS short wave channels exhibit larger drifts that make them unsuitable for climate trending, and they are avoided in this work. The AIRS Level 2 surface temperature retrievals only use short wave channels. We summarize how these short wave drifts impacts recently published comparisons of AIRS surface temperature trends to other surface climatologies.<p>